The try to stay red hot and the seek to maintain their dominance of their AL East rivals as part of Friday's 15-game schedule. The Mariners have won five straight and eight of their last nine, including an 8-3 victory against the on Thursday. They face off Richaun Holmes Jersey again Friday in Seattle at 10:10 p.m. ET. Meanwhile, the Yankees took a 6-5 victory against the in their series opener Thursday, New York's ninth win in its past 11 against Boston. Now they are set to start left-hander (7-3, 2.44 ERA) against Red Sox righty (0-1, 8.31 ERA) as Boston battles major injury i sues in their rotation.First pitch for the Yankees vs. Red Sox game is set for 7:10 p.m. ET. Caesars Sportsbook lists New York as a -160 favorite in its latest Red Willie Cauley-Stein Jersey Sox vs. Yankees odds, with Boston the +135 underdog. There are tons of opportunities for wagers on this full MLB schedule, and there is value if you really dig into the matchups. If you combine your favorite picks into a parlay, you can cash in huge. Before you make any MLB picks or parlays, The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 271-232 on top-rated MLB money-line picks since the start of the 2021 season, returning well over $500 Sacramento Kings Jeresy for $100 players. This is the same model that pegged the 2021 at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.Now, the model has locked in four confident MLB best bets for Friday. The parlay doesn't start until 8:10 p.m. ET, giving you plenty of time to make your MLB picks. If you succe sfully parlay the picks, you'd be looking at a payout of well over 16-1. You can Top MLB picks todaySportsLine Projection Model is really high on the (-225) to beat the (8:10 p.m. ET), with Milwaukee winning in well over 70 percent of simulations. The Brewers have won eight of the 10 matchups this year, and the Pittsburgh bullpen, which wasn't very good to begin with, is going to be ga sed. Pittsburgh is 29th in MLB in bullpen ERA (4.78) and 28th in WHIP (1.41), and the relievers allowed 12 runs in three innings against Jabari Parker Jersey the Yankees on Wednesday night.The Pirates then played a doubleheader Thursday, splitting with the , before traveling to Milwaukee. (2-7, 4.28 ERA) is expected to start for the Pirates opposite (1-6, 4.60), so this could be a slugfest. That gives the Brewers the advantage, as they score almost a full run more per game (4.6-3.7) and are fourth in MLB in home runs. (17 homers) and (16) have been mashing and could go off Friday night. Featured Game | Milwaukee Brewers vs. Pittsburgh Pirates Moneyline Spread Total MIL PIT How to make Friday MLB parlaysThe model has locked in three other best bets for Friday, all of them underdogs that can help you to a ma sive payday. Jahmi'us Ramsey Jersey . Which MLB picks should you target for Friday in a parlay offering a payout of more than 16-1? And which underdogs with excellent value are must-backs? .